What is the principle of fluorouracil treatment of tumors?

Fluorouracil

can inhibit the synthesis of deoxythymidine, an important precursor of DNA synthesis, and thus affect cell proliferation.

Moreover, it can be incorporated into DNA as a pseudometabolite, causing base pairing errors, resulting in DNA dysfunction, interfering with normal replication and transcription, and ultimately inhibiting tumor cell growth and division.

In addition, fluorouracil can block cells at certain stages of the cell cycle, especially S phase, preventing tumor cells from moving from this stage to the next stage, thus limiting tumor cell proliferation.

However, it should be noted that the drug should be used under the guidance of a doctor.