Pathogenesis of gastroduodenal ulcer

Gastroduodenal ulcer should refer to peptic ulcer, the pathogenesis is infection with Helicobacter pylori, long-term use of non-steroidal anti-inflammatory drugs, excessive acid secretion, etc.

1. Infection with Helicobacter pylori

If the patient's gastrointestinal tract is infected with Helicobacter pylori, local tissue damage due to pathogen invasion of gastrointestinal mucosa can cause peptic ulcer.

2. Long-term use of non-steroidal anti-inflammatory drugs

Some patients use ibuprofen, celecoxib, diclofenac sodium and other drugs for a long time to treat diseases. Due to drug damage to gastric mucosa and weakening the defense function of stomach and duodenum, it is easy to cause peptic ulcer.

3. Excessive acid secretion

If the patient has excessive acid secretion due to diet, mood and other factors, it is easy to cause gastric mucosa to be digested by gastric acid itself, resulting in peptic ulcer.