What are the causes of severe aortic regurgitation?

Aortic

valve

stenosis is caused by

.

When aortic

stenosis occurs, it is difficult for blood to enter the aorta through the aortic valve during diastole, resulting in pressure gradient between the left ventricle and the aorta, resulting in regurgitation. Bacterial endocarditis

is caused by bacterial infection. Inflammation stimulates the endocardium, which can lead to valve deformation and affect the blood flow of the heart aorta, resulting in severe aortic valve regurgitation.