What about nodular prurigo?

Prurigo nodularis is a chronic, inflammatory skin disease characterized by severe itching and nodular lesions. Its etiology is generally related to insect bites, gastrointestinal disorders, endocrine and metabolic disorders, and neuropsychiatric factors. The disease is more common in women, and skin lesions usually occur on the limbs, but can also be seen on the waist, buttocks, and most often on the side of the calves. In general, it is necessary to improve hygiene conditions, prevent insect bites, remove related incentives, and prevent local irritation. In specific treatment, glucocorticoid topical drugs can be selected for treatment, or combined with oral antihistamines, such as cetirizine, loratadine, etc. For more serious cases, oral thalidomide, tripterygium wilfordii, and glucocorticoid drugs can be considered. In physical therapy, cryotherapy, laser treatment, etc. can be selected, but specific diagnosis and treatment should be carried out under the guidance and advice of clinicians.