What causes pancreatic heterotopia

Ectopic pancreas may be caused by factors such as embryonic pancreatic tissue migration, endoderm cell differentiation, and endothelial tissue metaplasia.

1. Embryonic pancreatic tissue migration

During congenital development, pancreatic precursor cells are affected by adverse factors and cannot migrate correctly to normal locations. Ectopic pancreas occurs.

2. Differentiation of endoderm cells

Endoderm cells are pluripotent and can differentiate into various cell types in the body. When endothelial tissue abnormally metaplasia occurs in other parts, ectopic pancreas can occur.

3. Endothelial tissue metaplasia

During congenital development, endothelial tissue fails to migrate normally to the submucosa and transform into pancreatic tissue, which can lead to ectopic pancreas.