What causes Sjogren's syndrome?

Sjogren's syndrome (SS) is an autoimmune disease, the cause of which is still unclear, but it is believed to be related to a variety of factors, including genetic factors, immune system abnormalities, viral infection, environmental factors, hormone levels, etc. If there is Sjogren's syndrome in the family, others may be at increased risk. 2. Immune system abnormalities Autoimmune dysfunction is the core mechanism of Sjogren's syndrome. The body's immune system mistakenly attacks its own exocrine glands, such as salivary glands and lacrimal glands, resulting in impaired function, dry mouth, dry eyes and other symptoms. 3. Viral infections Certain viral infections may be associated with the onset of Sjogren's syndrome. For example, EB virus infection is thought to be involved in triggering or exacerbating autoimmune responses. 4. Environmental factors Long-term exposure to certain chemicals, radiation, and other environmental factors may affect the immune system and increase the risk of Sjogren's syndrome. 5. Changes in hormone levels in the endocrine system, especially fluctuations in hormone levels in women, may be related to the occurrence of Sjogren's syndrome. Women are significantly more affected than men, possibly related to the role of hormones such as estrogen. Sjogren's syndrome is a complex disease, and its exact cause is the result of multiple factors. For patients suspected of Sjogren's syndrome, comprehensive examination and evaluation, including autoantibody testing, salivary gland and lacrimal gland function tests, are needed to confirm diagnosis and develop individualized treatment. Early diagnosis and treatment are important to improve symptoms and prognosis.